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Animal experimental evidence Osteoclast precursor (RAW264.7) experiment: AOD 9604 significantly inhibited RANKL induced osteoclast formation, reduced the number of TRAP positive multinucleated cells, and decreased bone resorption pit formation

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Nausea is the most frequently reported adverse effect, potentially affecting thirty to forty percent of patients at some point during treatment, though the intensity typically diminishes over time as tolerance develops

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