Subsequently, numerous central and peripheral actions of ghrelin were described, including stimulation of gut motility and gastric acid secretion [5,6], modulation of sleep [79], taste sensation and reward seeking behavior [1016], regulation of glucose metabolism [1720], suppression of brown fat thermogenesis [2125], modulation of stress and anxiety [2628], protection against muscle atrophy [29,30], and improvement of cardiovascular functions such as vasodilatation and cardiac contractility [3134] (Figure 1)
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