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The HPA axis normally triggers cortisol release during stress, but chronic activation leads to elevated baseline cortisol, which is linked to weight gain, inflammation, and metabolic dysfunction

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During wound healing, it can be removed from existing extracellular proteins by proteolysis and used as a chemical attractant for inflammatory and endothelial cells It can increase the production of messenger RNA in collagen, elastin, proteoglycans and glycosaminoglycans in fibroblasts

Those figures come primarily from focal cartilage defect populations, where the evidence base is most developed

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Alexandre J, Batteux F, Nicco C, et al

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