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As discussed earlier, Semaglutide may influence sleep through various mechanisms, including its effects on blood glucose levels and possible interactions with brain receptors involved in sleep regulation

Similarly, melatonin or insulin can affect tissue clock gene expression, thereby resetting local circadian clocks 24,25

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Because there is a need for dosage adjustment based upon renal function, assessment of renal function is recommended prior to initiation of Januvia and periodically thereafter