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95% CI, 0.44-0.84

The discoloration is evident at birth or within the first year of life in more than half of affected individuals, and in the remainder, it becomes apparent around puberty

in the deficit of lactase, or ac

Whilst one study on L cell-like lines did not support a direct effect of metformin on L cells to mediate this effect [60], a more recent study has reported a direct effect of metformin on these cells, where an increase in the expression of the gene encoding proglucagon by metformin is mediated via a -cateninTCF7L2-mediated mechanism [63, 65]

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Available at: (Accessed November 16, 2020)