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doi: 10.1046/j.1524-475X.1994.20406.x
N Engl J Med 338:265266 Mannucci E, Ognibene A, Cremasco F et al (2001) Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese non-diabetic subjects
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The effect of semaglutide can begin within a few days, but optimal results may take several weeks
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