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Switch from semaglutide to tirzepatide when Nausea and vomiting remain severe beyond 8-12 weeks at the same dose

However, there are limitations specific to this study in addition to its retrospective nature and relatively small proportion of patients treated with GLP-1 RAs

Because GIP and GLP-1 do overlapping but distinct things in the body, and the combination produces effects that neither achieves alone

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These structural modifications reduce affinity for endogenous IGF binding proteins, resulting in altered stability and interaction characteristics in experimental systems compared to native IGF-1