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Despite its prevalence, HFpEF has historically posed significant therapeutic challenges due to its heterogeneous pathophysiology and limited response to treatments proven effective in heart failure with reduced ejection fraction (HFrEF)

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doi: 10.1073/pnas.85.16.5804 25 PihlajamakiJBoesTKimE-YDearieFKimBWSchroederJet al

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cerevisiae GSH2 gene

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