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The clinical evidence is clear, the mechanism is understood, and patients report real symptom relief

Animals were housed in a conventional animal facility with 12 h light/dark cycles and fed ad libitum

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Carnitine supplements in the prevention of valproic acid toxicity Raskind and El-Chaar [41] extensively reviewed the patho-physiology and significance of VPA-induced carnitine deficiency and evaluated the literature pertaining to carnitine supplementation during VPA therapy in children