Both astrocytic uptake of neuronally derived GABA and cell-autonomous astrocytic synthesis of Put-GABA have been proposed as sources of this circadian GABA signaling (Patton et al., 2023
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The microdosing approach can be particularly helpful at this level, where splitting the dose can reduce peak-related GI effects
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Additionally, it is in a binary system with a brown dwarf, making this a particularly intriguing group to study