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The semaglutide and tirzepatide trials changed that expectation: Semaglutide 2.4 mg once weekly produced average weight loss around 15% at ~68 weeks in adults without diabetes, with a substantial fraction of participants losing 1520% of baseline weight

doi: 10.1016/j.yexcr.2015.06.017 51 KaiAKChanLKLoRCLeeJMWongCCWongJCet al

Figure 3: Head-to-head efficacy comparison restricted to Standard-design, Non-T2D trials

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