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New @NEJM review on GLP-1 receptor agonists just out: effects on glucose, weight, cardiovascular outcomes, #MASLD and kidney outcomes but important questions remain about durability, lean mass (muscle + bone) loss, and long-term safety

A phase 1 study of pegylated recombinant arginase (PEG-BCT-100) in combination with systemic chemotherapy (capecitabine and oxaliplatin)[PACOX] in advanced hepatocellular carcinoma patients

Initially, we determined whether pegvisomant treatment inhibits GH signaling in mice

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Ask your doctor about concerns related to hypoglycemia when drinking alcohol while taking GLP-1 drugs like Ozempic, especially if youre taking other medicines to treat diabetes

However, when blood sugar is high, the activity of the hexosamine pathway increases, activating the Sp1 pathway