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In rats, GDNF increased BCL2, an important protein that prevents cell death [22]

Importantly, correlation analysis of AGEs bone content with LEF1 gene expression levels showed a negative association (r=-0.55

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Simultaneously, the assembly and activation of the NLRP3 (nucleotide-binding domain-like receptor family pyrin domain containing-3) inflammasome complex, regulated by NF-kB, are enhanced in neurons, microglia, and astrocytes within the trigeminal ganglia, trigeminal nucleus caudalis, and cortical areas (9, 10, 39, 47)

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Efficacy was calculated using the following formula: During a subjective evaluation, participants were involved and a scoring scale was used to indicate minimal, moderate, good, or very good improvement in skin tone