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[ The second step in GSH synthesis is catalyzed by GSH synthetase (GS)

J Am Coll Cardiol

Neurotox Res 37:977986 Muralidharan P, Sarmah S, Zhou FC, Marrs JA (2013) Fetal alcohol spectrum disorder (FASD) associated neural defects: complex mechanisms and potential therapeutic targets

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Within the affected group 17 were diagnosed with Stage 1 Konzo, 7 with Stage 2 konzo and 5 with Stage 3 konzo, however proteomic analysis on the discovery cohort were not segregated based on stage of the disease

First, it did not compare metformin with a well-established pharmacological control, which limits direct benchmarking against existing therapeutic options