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124 Additionally, abnormal regulation of the cell cycle is one of the core causes and key mechanisms that trigger and exacerbate genomic instability

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However, patients should be advised to report symptoms suggestive of liver injury, including: Persistent nausea or vomiting unrelated to expected GI side effects Right upper quadrant abdominal pain (which may also indicate gallbladder disease, a known risk with GLP-1 therapy) Jaundice (yellowing of skin or eyes) Dark urine or pale stools Unexplained fatigue or malaise Clinicians should maintain a low threshold for investigating these symptoms with comprehensive liver function tests, including ALT, AST, alkaline phosphatase, bilirubin, albumin, and INR/prothrombin time

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Too much and side effects intensify unnecessarily

International Journal of Clinical Pharmacy, 46(2), 488495