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Whether the spectacular preclinical pharmacology of GLP-1R/GcgR co-agonists will translate through successful phase 3 registration trials is a question that will be answered in the coming years, but the pursuit of multifunctional, targeted therapeutics is destined to continue

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Therefore, the purpose of this scoping review is to characterize the current evidence base for peptide therapies relevant to musculoskeletal care, with emphasis on BPC-157, thymosin beta-4 derivatives, and related agents, and to define safety considerations and perioperative implications for orthopaedic surgical patients, including those undergoing TJA

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Zepbound is a brand-name tirzepatide medication used for chronic weight management in eligible adults