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To overcome these problems, various halogenated derivatives (e.g., chlorinated or boronated PBN), alkylated derivatives having a lipophilic tail (e.g., those with dodecyl chains), bifunctional derivatives (e.g., GS-PBN, Mito-DEPMPO, 5-ChEPMPO, DECPO, and 4-HMDEPMPO), conjugates with drugs or targeting molecules (such as PEG or heparin, that both can cross the BBB), dimers, and cyclodextrin polymers have been developed in the last few years (Wang et al., 2021

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CJC-1295 (no DAC) is similarly well-tolerated

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Sensitivity Analyses The base-case result was shown to be robust across all one-way sensitivity analyses (Table 3)

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(2019) reported a negative correlation between the NAFLD activity score and the abundance of Akkermansia

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