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Date of First FDA Approval: October 21, 2019 Indications Trikafta Is FDA-approved for: Cystic fibrosis (CF) WAC of Trikafta: $311,741 per year Why It Sold So Well: Trikafta is approved for the treatment of CF in patients aged two years and older who have at least one F508del mutation in the CFTR gene or a mutation in the CFTR gene that is responsive based on in vitro data

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It requires sterile technique, causes discomfort for needle-averse individuals, creates potential injection site reactions, and demands careful rotation to avoid tissue damage over extended protocols

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