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and cognitive control regions (dorsolateral prefrontal cortex, inferior frontal cortex and cingulate cortex) ( There is strong evidence for a link between the menstrual and/or estrous cycle and appetite

One in-trial AE type was chosen (GI events) and tested both for treatment-dependent and treatment-independent linear and non-linear effects of age on AE incidence

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Age-associated NF-kappaB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function

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In the MAD cohorts, the highest dose of 420 mg Q4W resulted in a BW change of -14.5% by day 85