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Copper is also used in superoxide dismutase, an enzyme that handles oxidative stress, and oxidative stress is one driver of fine lines and dull tone after years of UV exposure

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doi: 10.1016/S0016-5085(85)80132-3 165 SinghR

Orphan drug designation for a narrow indication like GH-deficient post-bariatric patients could provide 7 years of market exclusivity and offset this concern 20