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The industry must now address critical challenges, including pricing negotiations, payer coverage limitations, supply constraints and the preservation of muscle mass during weight loss, with solutions emerging through novel mechanisms targeting amylin, cannabinoid receptors and activin pathways. 1 Sales Projections Far Outpace Other Drugs on Clarivates 2026 Watch List An FDA decision on orforglipron is expected by March 2026, with Clarivate projecting retatrutide will be ready for launch in 2028

Indeed, these included the overexpression of MTs [84]

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2025;86(4):25f16139

Cotter, L., Rae, M., McGough, M., Panchal, N., et al

For all the hype over GLP-1s, Americans have struggled to access these weekly injections