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After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis

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When GLP-1 medications bind to these receptors, they can reduce hunger signals and increase feelings of fullness

Koehler JA, Baggio LL, Yusta B, Longuet C, Rowland KJ, Cao X, et al

(1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene