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This is subjective and not a validated pharmacokinetic endpoint

Semaglutide works by binding to GLP-1 receptors

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Comparing the efficacy and safety of glucagon-like peptide 1 receptor agonists with sodium-glucose cotransporter 2 inhibitors for obese type 2 diabetes patients uncontrolled on metformin: a systematic review and meta-analysis of randomized clinical trials

Unfortunately, we have no follow-up information from those patients to assess whether study participants maintained their weight loss after stopping the medication