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The major clinical trials, like the groundbreaking Phase 2 study published in the New England Journal of Medicine, were focused on primary endpoints relevant to its intended therapeutic use: weight reduction, HbA1c levels, lipid profiles, and safety

Just like retatrutide, you get weight loss with a side bonus of low-dose statin reduction in cholesterol

Here are some key points to consider: 1

JAK inhibitors represent another class of targeted therapy, but like anti-TNF agents, they come with significant immunosuppressive effects

On the heart and circulation, the Phase 2 data show consistent reductions in resting blood pressure of approximately 5 to 8 mmHg at the higher doses, alongside large improvements in the cholesterol pattern most associated with heart disease

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