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Cosmetic medicine must consider authorisation, manufacturing quality, patient selection, long-term monitoring and whether the expected benefit justifies the risk

However, retatrutide dose escalation schedules differ from tirzepatide, starting at lower doses and escalating more gradually in many research protocols

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There is currently no clinical trial evidence, regulatory guidance, or peer-reviewed data supporting the combined use of tesamorelin and retatrutide, and both remain unlicensed in the UK