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PUFA, like omega-3s, with the last double bond at the third carbon from the omega end of the chain, and omega-6s, with the double bond at the sixth carbon from the omega end of the chain, are considered good fats and an important part of a healthy diet because they are essential, since humans, and other animals, cannot synthesize them and must introduce them with the diet
To improve corneal residence time, penetration, and targeted administration of natural compounds, future research should use in situ gels, nanoparticle-based carriers (liposomes, polymeric NPs), and contact lens drug delivery