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GLP-1 medications (semaglutide, tirzepatide, etc.) have helped many people reach healthier weights, but relying on them indefinitely can come with trade-offs: loss of muscle, facial volume changes (the so-called Ozempic face), sagging or loss of gluteal fullness, and difficulty maintaining tone when meds are reduced or stopped

Scherer SW, Otulakowski G, Robinson BH, Tsui LC

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9 The A1R-CT peptide is administered through a nasal spray

MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence

But others say it can be bought by anyone, so theres a risk of non-professionals administering it