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[5] The researchers also note that IR and IGF1R act as identical portals to the regulation of gene expression, with differences between insulin and IGF-1 effects due to a modulation of the amplitude of the signal created by the specific ligand-receptor interaction. The IGF-1R is referred to as the physiologic receptor due to its potential higher affinity (approximately 100 times higher) for IGF-1 as compared to the insulin receptor

AEDG peptide regulation of the expression of human circadian rhythm genes upon accelerated aging of the pineal gland

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doi: 10.3390/jpm14070717

(6) Plates were washed twice in tap water and dried overnight at room temperature

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