Orforglipron is intended to complement, rather than replace, Lillys existing portfolio. Pfizer is looking to expand its portfolio of obesity medicines with the just-announced acquisition of Metsera, a clinical-stage biopharma
Meal preparation strategies help ensure healthy food choices are readily available when appetite is reduced
The introduction of GLP-1 receptor agonists like semaglutide (Wegovy) and tirzepatide (Zepbound) has fundamentally changed what is clinically achievable, with patients routinely losing 15-22% of their body weight under proper medical supervision
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GLP-1 injection should usually be given in the front or outer part of the upper thigh
If CNS-targeted (or perhaps craving-optimized) compounds can be developed, these could address multiple substance use disorders with a single mechanism
