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Moreover, there was a significant reduction in LS-mean change in AUC Glucose0-2h from baseline across the high GLP-1 group [LS-mean change from baseline -263.89 mmol/L (95% CI -384.74, -143.04)]

However, effects are dose-responsive smaller doses usually mean smaller changes

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As more non-weight indications emerge, including potential applications for addiction, Alzheimer disease, fatty liver disease, and chronic kidney disease, the relevance of BMI as the primary gatekeeper will diminish

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They point to effects beyond appetite suppression, from reduced inflammation to possible direct signalling on tumour cells. F&B takeaway: It almost goes without saying that GLP-1s for cancer prevention or treatment would dramatically accelerate their adoption, both in private use and in public health systems, shifting them firmly into the health space