Pre-infusion CAR T cells of long-term responders (LTR) have increased oxidative phosphorylation, fatty acid oxidation, and pentose phosphate pathway activities, higher mitochondrial mass, tighter cristae, and lower mTOR expression compared to products of short-term responders
Conjugation proceeds as a nucleophilic displacement reaction with the glutathione anion (GS - ) serving as the nucleophile
In contrast, Nrf2 phosphorylation by GSK-3 at serine residues of Neh6 domain ( Figure 4B ) inhibits its activity by promoting -TrCP-mediated ubiquitination and degradation of Nrf2 (Rada et al., 2012)
Data were analyzed by Pearsons correlation ( D , G , and H ), 2-way ANOVA ( I K ), and 2-sided Mann-Whitney test ( E )
Oxidative stress-induced glutathionylation has been recognized as a mechanism for induction and regulation of several proteins, including Grx (glutaredoxin), Trxs (thioredoxin) and GSTs, which are involved in environmental stress responses (Dixon et al
Ann Transl Med 8:852852 Xue R et al (2019) Coenzyme Q10 Ameliorates pancreatic fibrosis via the ROS-triggered mTOR signaling pathway
