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CagriSema's path depends on the complete package of REDEFINE data and regulatory review

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Its first Phase 3 readout reported roughly 28.7% weight reduction at 12 mg over 68 weeks 5 a meaningful six-percentage-point ceiling advantage over tirzepatides SURMOUNT-1 peak of 22.5% over 72 weeks 13

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

Oral formulations bypass the stomach initially (absorbed sublingually), which some IBS-D patients prefer because it avoids concentrated gastric drug delivery

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