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Currently, the small application range of targeted therapy drugs and recurrence and drug resistance after radiotherapy and ablation treatment lead to the unoptimistic overall treatment effect of advanced liver cancer, and the 5-year survival rate is low (Schlachterman et al., 2015)

The region accounts for a substantial revenue share owing to high prevalence of type 2 diabetes and obesity, strong healthcare infrastructure, and favorable reimbursement policies

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This may lead to elevated levels of homocysteine