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10.1111/bjh.12016 55 RileyD

Clin Med

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reported that treatment of human islets with sitagliptin resulted in a sevenfold increase in islet active GLP-1 content ( in vitro treatment of human islets with linagliptin (114) and vildagliptin (115) has been shown to stabilize active GLP-1 in islet supernatants and protect non-diabetic human islets from experimentally induced beta-cell damage (114)