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The higher-concentration versions cost more to produce because raw ingredient costs scale with potency, and 503B compounding facilities must verify potency through third-party lab testing

doi: 10.1111/j.1525-1438.2005.00432.x 121 Villalona-CaleroMAOttersonGAWientjesMGWeberFBekaii-SaabTYoungDet al

A note for women in perimenopause: Mitochondrial function and metabolic efficiency naturally decline during the perimenopausal transition as estrogen which supports mitochondrial biogenesis and energy production decreases