Our DIA-MS proteomics analysis of early ring-stage parasites demonstrated that several proteins involved in the parasite respiratory chain, a known source of reactive oxygen species (ROS) 49 , are downregulated in parasites with PfK13 mutations, and since GSH scavenges ROS 23 , less ROS could contribute to the elevated GSH levels in these resistant parasites
Influenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell death
& Zimmerman, W
Additional testing includes stability assessment under defined storage and handling conditions
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In addition, it can also inhibit or deactivate the tyrosinase enzyme which supports melanin production, and help in the change from eumelanin to phaeomelanin production
