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Kee and Hong also investigated these effects, confirming arctigenin (2, 10, and 50 M) reductions on histamine, RNA expression of chemokines macrophage inflammatory protein (MIP)-1, MIP-1, macrophage inflammatory protein (MCP-1), and Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted (RANTES) and pro-inflammatory cytokines, including IL-1, IL-6, IL-8, and TNF-, and protein expression of p-ERK/ERK, p-JNK/JNK, p-p38/p38 and NFB phosphorylation in HMC-1 mast cells [85]

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Its skin-lightening effect was detected incidentally

It supports relaxation and wellness but is not a treatment for medical conditions related to fatigue or stress

GPX8 is similar to GPX7 because both have low glutathione peroxidase (GSH) activity, mainly due to the lack of domains bound to GSH

Some people experience a cool feeling in the arm or a mineral taste in the mouth, but this is all normal