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This was explained in a case report by Eileen Conaway, DO and Brian Browning, DO titled Neural Prolotherapy for Neuralgia published in the Journal of Prolotherapy

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Applications in Animal Aging Models Animal aging models (such as naturally aged mice, D-galactose-induced aging mice, SAMP8 accelerated senescence mice, etc.) are core carriers for simulating human aging and verifying the efficacy of anti-aging drugs

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