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Melatonin, which is closely linked to immune system, exhibits a progressive decrease throughout lactation in both vaginal and cesarean-section deliveries, with levels being notably higher in colostrum [7, 44]

Three reviewers (RZ, QH, PS) graded the strength of evidence as high, moderate, low and very low degree, following five assessment criteria which were risk of bias, inconsistency, indirectness, publication bias, and imprecision

This is true at any dose

Due to its central role in metabolic reprogramming in diseases such as cancer and type 2 diabetes, PDK has emerged as a therapeutic target, although existing inhibitors have not progressed successfully to clinical use

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Reference: Chen, J.-C., Huang, Y.-N., Tsou, M.-Y., Chen, S.-C., Yang, S.-F., Liu, Y.-L., & Su, P.-H