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TB-500 Dosing: 1,250 mcg (50 units) twice weekly (Weeks 14), then once weekly (Weeks 512)

Informed consent was obtained in accordance with the Declaration of Helsinki

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The catheter tip was placed at the level of the aortic arch

Caruncho, University of Victoria, Canada Reviewed by Renan Santo, University of Maryland, United States Liangliang Zhou, Jiangxi Science and Technology Normal University, China Minquan Zhang, Shanghai University of Traditional Chinese Medicine Shanghai, China, in collaboration with reviewer LZ Updates Copyright 2026 Simes, Braga, Assmann and Bagatini