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Further, a glutathione conjugate can serve as a marker for the presence of a reactive electrophile providing valid information for the evaluation of a drug candidate

These DAMPs bind to pattern-recognition receptors on antigen-presenting cells, which in turn activate the adaptive immune response

Taken together, this is the first study to describe the hepatic metabolome after ischemic AKI in a murine model and demonstrates that there is significant liver-kidney crosstalk after AKI

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Shechter, A., Lesperance, P., Ng Ying Kin, N