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All the reactions were operated under a nitrogen atmosphere using a Schlenk-line system and a glovebox to protect air- and moisture-sensitive chemicals

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Based on reported multiple cellular and pathological changes, inhibition of GSK-3 activity has been used to test agents and drugs on experimental rodent models, and on AD patients 9,14

Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration

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