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Mejora de la bioenergtica mitocondrial cerebral: el cerebro es extremadamente dependiente de la funcin mitocondrial

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Treatment with JHU-083 potentiated the antitumor effect of the EGFR peptide vaccine (EVax) by increasing tumor infiltration of CD8+ T cell and CD4+ Th1 cells and inhibiting immune suppressive cells, including regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), granulocytic myeloid-derived suppressor cells (G-MDSCs), and tumor-promoting CD4+ Th17 cells in the syngeneic lung tumor models carrying human epidermal growth factor receptor EGFR L858R mutation and transgenic EGFR L858R -driven murine lung cancer model [98]