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For example, SLCO1B1 *5/*15 variants are linked to reduced hepatic clearance and higher systemic exposure, which may exacerbate oxidative stress and cholestatic injury

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This comprehensive guide examines common and serious adverse effects, management strategies, contraindications, and warning signs requiring immediate medical attention to help patients and healthcare providers optimize treatment outcomes

Various structural alterations were made at the N-terminal such as substitution of D-norleucine for L-norleucine, N-acetylation of norleucine, and replacement of norleucine with GABA in order to improve overall stability by reducing susceptibility to aminopeptidases

10.1093/ecco-jcc/jjab050 36 WangJ.CaoL.ZhuY