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This muscle loss undermines metabolic rate, functional capacity, and long-term weight maintenance

It suppresses hunger hormones, helping reduce food intake and overall daily calorie consumption

Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease

Primary endpoint analysis was performed on the full analysis set (FAS), comprising all randomised participants who were exposed to at least one dose of study product and completed at least one period on 2G oral semaglutide and at least one period on 1G oral semaglutide

The STEP 1 trial showed average weight loss of 14.9% over 68 weeks

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