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A topical application of Tregs or the combination with CCR4 Treg homing receptor ligand CCL22 (64) by local needle-free jet injection of DNA (20) or CCL22-encoding plasmid DNA (64) may help resolve that issue

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Clin Cancer Res 6:12051218 Hall MD, Okabe M, Shen D-W, Liang X-J, Gottesman MM (2008) The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy

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