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This results in increased stimulation of anorexigenic POMC/CART neurones and decreased activity of orexigenic NPY/AgRP neurones, profoundly altering appetite signals (Trapp and Brierley 2022)

Despite this, it plays an important role in postprandial glucose regulation and energy balance

Pre-clinical work with the GIPR antagonist AT-7687 shows similar synergy when paired with GLP-1RAs 1

Pioneering technology now allows the active ingredients to reach the bloodstream intact, a testament to years of dedicated research

Paracellular ion channel at the tight junction