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In humans, yerba mate seems to reduce cholesterol levels

Farrar, and L

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But for other doses, the unit numbers are less clean (33 units for 2.5 mg requires careful measurement)

Self-assembled polydopamine nanoparticles improve treatment in Parkinsons disease model mice and suppress dopamine-induced dyskinesia

GLP1R agonists increase heart rate and might not be beneficial in individuals with severe left ventricular dysfunction, reduced ejection fraction and/or a history of repeated hospitalization for heart failure