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One reason Matrixyl remains relevant is that topical palmitoyl pentapeptide has some human clinical data behind it, including controlled work showing improvement in photoaged facial skin over a period of weeks

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AEDG peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: Possible epigenetic mechanism

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Additionally, understanding an individuals genetic predispositions can inform the selection of therapeutic modalities and the intensity of rehabilitation exercises