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A study by Zhu et al (136) identified restoring RIPK3 expression to reverse R-2-hydroxyglutarate-induced necroptosis in isocitrate dehydrogenase-mutant AML cells as a potential therapeutic strategy for patients with AML

Radical species include superoxide radical (O2_), hydroxyl radical (OH), alkoxyl (RO) and peroxyl (ROO) while non- radical species contains hydrogen peroxide (H2O2), singlet oxygen (1O2), ozone (O3), and hypochlorous acid (HClO)

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